In the production practice of livestock and poultry breeding, almost 100% of some relatively serious infectious diseases or relatively serious secondary infectious diseases have different degrees of bacterial factors involved in the pathogenesis. However, due to the widespread abuse of antibacterial drugs in the past, it has also brought serious bacterial resistance problems to the aquaculture industry, so many antibacterial drugs are used according to the dosage specified decades ago. Basically, it can't reflect its due therapeutic effect.
Here is an antibacterial drug that was once used very widely. For example, "amoxicillin" is the most common in veterinary clinics. It is a broad-spectrum antibacterial drug that is well absorbed orally. In the body, it exerts a bactericidal effect by inhibiting the synthesis of bacterial cell walls. The principle is to make sensitive bacteria quickly become spheroids, burst and dissolve, so that it has a strong and rapid killing effect on Gram-negative bacteria and positive bacteria. It also has a significant and rapid killing effect on the spirochetes that cause digestive system diseases in livestock and poultry.
Amoxicillin is relatively stable to gastric acid when taken orally, and is absorbed quickly in the body and acts quickly. Its effect on sensitive bacteria can prevent it from reproducing, and its bactericidal effect is better than that of ampicillin. Amoxicillin is well absorbed, which is also the pharmacological basis for its suitability for large-scale breeding groups drinking water administration; about 1 hour after taking it, the peak blood concentration can be reached, which is 2.5 times that of the corresponding dose of ampicillin taken orally under the same conditions. This is why amoxicillin acts so quickly. Food can affect how quickly a drug is absorbed, but not how well it is absorbed. Therefore, when amoxicillin is given clinically for the treatment of systemic infectious diseases, it is best to control feeding and concentrate administration on an empty stomach.
However, when it is used to treat infectious diseases of the digestive system of the gastrointestinal tract, the above usage is wrong. At this time, it needs to be administered together with food or after feeding, and the administration time needs to be extended, and the administration cannot be concentrated. Otherwise, the clinical therapeutic effect is not very good or almost no effect can be seen. The fundamental reason is that the drug has been absorbed into the body, and the concentration of the drug distributed in the gastrointestinal tract or the effective drug concentration maintained is not high or the time is too short. Effectively and comprehensively inhibit the growth and reproduction of bacteria, so as to reflect the due therapeutic effect of medication.
The pharmacology of the drug is relatively clear. Amoxicillin has a relatively broad antibacterial spectrum against sensitive bacteria clinically. It has a relatively good effect on Gram-positive bacteria and Gram-negative bacteria that are common in animal and veterinary clinics. It is the beginning of this sentence "sensitive bacteria". In fact, amoxicillin is the most important thing for clinically effective medication! Because the veterinary diagnosis results of many livestock and poultry diseases show that the infection of Gram-negative bacteria such as Escherichia coli and Salmonella is the most extensive and common.
Unfortunately, however, amoxicillin currently has the highest rate of resistance to these Gram-negative bacteria. Therefore, when amoxicillin is used to treat the above-mentioned Gram-negative bacterial infection diseases, it is usually difficult to receive better drug effects clinically. The most fundamental reason here is that amoxicillin is resistant to these Gram-negative bacteria. Therefore, if any veterinary drug manufacturer's amoxicillin product is effective against the diseases caused by the above-mentioned Gram-negative bacteria, most of them have added other additional sensitive antibacterial or synergistic ingredients.
Then, according to the statistical analysis data from the clinical monitoring of veterinary treatment, the more serious bacterial diseases such as pericarditis, perihepatitis, endocarditis and liver capsule caused by Gram-negative bacteria such as Escherichia coli and Salmonella , amoxicillin sulfate colistin sulfate soluble powder and apramycin sulfate soluble powder are combined into a prescription, which is used to treat the above-mentioned Escherichia coli, Salmonella, Pasteurella hemolyticus, Proteus and other Gram-negative bacteria in chickens. Bacterial diseases can receive relatively ideal drug treatment effect clinically.
In this prescription, although amoxicillin is broad-spectrum antibacterial and apramycin sulfate is also broad-spectrum anti-gram-negative bacteria, the medical scope of this prescription is still relatively narrow. It also only has a relatively good therapeutic effect on heart, liver and digestive tract diseases caused by Gram-negative bacteria, and its effect on respiratory diseases and genitourinary system infections caused by bacteria is not very prominent. This may be related to the change in the pharmacokinetic distribution in the body after amoxicillin sulfate colistin sulfate soluble powder and apramycin sulfate soluble powder are formulated into a prescription.
Of course, this is the scope of research by scientists. For our vast number of veterinary drug users and farmers, as long as we ensure drug safety (animal safety and food safety), effectively and economically control animal diseases, and find out the reasons and The mystery is a matter for veterinary drug manufacturers and scientists. Farmers are more concerned about effectively controlling diseases and ensuring the health of animals, and not delaying their meat growth, egg production and milk production, because these directly affect the breeding efficiency and income.
So, if the chicken has a respiratory disease, how to use amoxicillin sulfate colistin sulphate soluble powder for treatment? We have already used veterinary medicine in front of us. Every veterinary drug product is dead, it is like that when it is born, and everything in it is fixed. However, the various diseases that are occurring in the clinic are not fixed. They will also vary in thousands of ways due to different regions, farms, animal species, animal ages, and feeding and management conditions. How to deal with the ever-changing diseases with the same products? This requires group technology. Amoxicillin does not cure pericarditis and perihepatitis most of the time, but after combining amoxicillin sulfate colistin sulfate soluble powder and apramycin sulfate soluble powder together, this veterinary prescription is effective for a variety of Gram It is more effective in the treatment of pericarditis and perihepatitis caused by Klebsiella- negative bacteria.
The reason is that apramycin sulfate solves the problem of drug resistance of amoxicillin, and amoxicillin promotes the absorption of colistin sulfate and apramycin sulfate, making this prescription suitable for Gram-negative bacteria. Treatment of systemic infectious diseases can be effective. As mentioned in the special article, amoxicillin sulfate colistin soluble powder combined with baicalin (baicalin extract) is very effective in the treatment of non-viral respiratory diseases that are popular in this season, and the clinical recurrence rate is low. The treatment is relatively thorough. Generally, it does not appear repeatedly, and eventually develops into air sacculitis.
This is the active use of veterinary medicine. Every veterinary drug product is dead, it is like that when it is born, and everything in it is fixed. However, the various diseases that are occurring in the clinic are not fixed. They will also vary in thousands of ways due to different regions, farms, animal species, animal ages, and feeding and management conditions. How to deal with the ever-changing diseases with the same products? This requires group technology.
Amoxicillin does not cure pericarditis and perihepatitis most of the time, but after combining amoxicillin sulfate colistin sulfate soluble powder and apramycin sulfate soluble powder together, this veterinary prescription is effective for a variety of Gram It is more effective in the treatment of pericarditis and perihepatitis caused by Klebsiella-negative bacteria. The reason is that apramycin sulfate solves the problem of drug resistance of amoxicillin, and amoxicillin promotes the absorption of colistin sulfate and apramycin sulfate, making this prescription suitable for Gram-negative bacteria. Treatment of systemic infectious diseases can be effective.
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Written By lucas lee
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